Dr Carl Kuschel and Brenda Hughes
January 2001
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Suxamethonium Administration




Slow IV Injection

  1. Administered only by medical staff/NS-ANP.
  2. Further dilution not required.
  3. Filter prior to administration through a 5 micron filter.
  4. Administered by slow IV injection.
  5. Compatible with NS, D5W.
  6. Do NOT mix with other drugs, IV solutions, blood or blood products.

Observation and Documentation

  1. Monitor for signs of adverse reactions.
  2. Have supportive therapy: resuscitation equipment, oxygen and mechanical ventilation on hand.
  3. Continuous cardiorespiratory monitoring.
  4. Monitor oxygenation with blood gases, or pulse oximetry.
  5. Evaluate and document patient response to drug, recovery.
  6. Does NOT alter pain threshold.
  7. Monitor temperature closely.


Selected References

1 Cook DR, Wingard LB, Taylor FH. Pharmacokinetics of succinylcholine in infants, children, and adults. Clin Pharmacol Ther 1976; 20:493.
2 Nugent SK, Laravuso R, Rogers MC. Pharmacology and use of muscle relaxant in infants and children. J Pediatr 1979; 94:481-7.
3 Cook DR. Muscle relaxants in infants and children. Anaesth Analg 1981; 60:335-43.
4 Spear TM. Anaesthesia for premature and term infants: perioperative implications. J Pediatr 1992; 120:165-76.