Chloral hydrate

Reviewed by Dorothy Cooper
February 1997
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Chloral Hydrate Administration




  1. Shake the bottle before use.
  2. Administer with milk.

Observation and Documentation

  1. Monitor for adverse reactions.
  2. Monitor heart rate and respiratory rate.


Selected References

1 Sellars EM, Lang ML, Cooper SD, Koch-Weser J. Chloral hydrate and triclofos metabolism. Clin Pharmacol Ther 1973; 14:147.
2 Reimche LD, Samkaran K, Heindmarsh KW, Kasian GF, Gorecki DKJ, Tan L. Chloral hydrate sedation in neonates and infants: Clinical and pharmacologic considerations. Dev Pharmacol Ther 1989; 12:57.
3 Mayers DJ, Hindmarsh W, Sankaran K, Gorecki DKJ, Kasian GF. Choral hydrate disposition following single-dose administration to critically ill neonates and children. Dev Pharmacol Ther 1991; 16:71-7.
4 Laptook AR, Rosenfeld CR. Chloral hydrate toxicity in a preterm infant. Pediatr Pharmacol 1984; 4:161-5.