Vancocin CP

Reviewed by NICU and Pharmacy
November 2011
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page


Management of Vancomycin Administration




  Vancomycin DBL Vancomycin other brands
Powder space:

0.5 ml


Water to be added:

9.5 ml



500 mg in 10.0 ml

500 mg in 10.0ml

  1. Use appropriate powder space and reconstitute vial with Water for Injection to give a solution of 50mg/ml.
  2. Then further dilute this solution to 5 mg/ml with sodium chloride 0.9% or glucose 5%.
  3. For fluid restricted patients a solution of 10mg/ml can be used, but this must be infused via a central line. The higher concentration increases the risk of infusion-related adverse events
  4. Each dose must be administered over at least one hour, preferably 2 hours. Can be infused through a 0.2 micron filter.
  5. As vancomycin is irritant to the tissues, avoid intramuscular injection and extravasation when given intravenously.
  6. Flush line with sodium chloride 0.9% before and after infusion.
  7. Incompatible with: blood or blood products, cefotaxime, cefoxitin, ceftazidime, cefuroxime, heparin.

Observation and Documentation




Neonatal Formulary 6: drug use in pregnancy and first year of life, Compiled by Edmund Hey, BMJ publishing, Wiley-Blackwell 2007.


Vancomycin Data sheet. Auckland: Pacific Pharmaceuticals Ltd; 2005.


Paediatric Formulary. (5th ed.) Guy’s, St. Thomas’ and Lewisham Hospitals. 
4 Baxter K(ed). Stockley’s Drug Interactions (7th ed.). London: Pharmaceutical Press, 2006.
5 Trissel LA (ed). Handbook on Injectable Drugs (14th ed.). Bethesda: American Society
6 Sweetman SC, (ed.).Martindale The Complete Drug Reference (35th ed.).London: Pharmaceutical Press, 2007.
7 Auckland District Health Board. LabPlus Laboratory Handbook. Updated 6 December 2007.
8 Fary R, Smith R, (eds.). Neonatal Pharmacopoeia (2nd ed.). Melbourne: Pharmacy Department, The Royal Women’s Hospital, 2005.
9 Kemp C, McDowell J (ed). Paediatric Pharmacopoeia (13th ed). Parkville, Melbourne: Pharmacy Department, Royal Children’s Hospital, 2002.